Buy Vardenafil Hydrochloride powder
Is a phosphodiesterase inhibitor PDE5 used to treat impotence ( erectile dysfunction ) and is marketed under the name of Levitra ( Bayer AG ) and Vivanza ( GSK ). Developed by Bayer, Germany, and first listed in the US in 2002. It is ten times more powerful than sildenafil. Buy Vardenafil Hydrochloride powder
The PDE-5 inhibitor suppresses the action of the enzyme called PDE-5 involved in erection in the corpus cavernosa and exerts its effect by acting on the NO-operated nerve in the periphery of the penis to dilate blood vessels and promote blood flow to encourage sustainability of erection. Buy Vardenafil Hydrochloride powder
Simple description of Vardenafil Hydrochloride powder
Vardenafil Hydrochloride is very popular due to immediate effect, strong erectile power, prolongation of ejaculation time, few side effects. For the general public there is no problem, but dialysis patients, for example, are contraindicated to take only Vardenafil Hydrochloride formulation. Also, there is no indication for people over 65 years old.
In addition to the ED treatment effect of Vardenafil Hydrochloride, an extension effect of ejaculation time is known as a secondary effect. The effect of prolonging the ejaculation time is not examined in Vardenafil Hydrochloride 5 mg and the effect of prolonging the ejaculation time is recognized with a significant difference at 10 mg or more. This is an unrecognized effect for sildenafil which is a component of Viagra, tadalafil which is a component of Cialis. There is a report that the time to ejaculation when continuing sexual activity without taking rest from after insertion of 10 mg of Vardenafil Hydrochloride has been extended from approximately 49 seconds to 83 seconds and reports that it extended from 36 seconds to 7.5 minutes but a side effect Even though it does not extend the ejaculation time of all people.
It turns out that if it becomes ED and the hardness of the penis decreases, the sensitivity increases and the ejaculation time gets faster. For that reason, it is important to take Levitra for premature ejaculation of ED merger to keep firm penis hardness, to use dapoxetine preparation of premature ejaculation drug (Prelizy, Posetto etc.) together, many are satisfied with combination of Vardenafil Hydrochloride and Dapoxetine You will be able to do sexual intercourse.
Pharmacological action ,mechanism of action of Vardenafil Hydrochloride powder
During sexual stimulation, neurons and vascular endothelial cells in the corpus cavernosum release nitric oxide NO and activate soluble guanylate cyclase, resulting in the formation of cyclic guanosine cGMP. A series of biochemical reactions are then stimulated, which ultimately causes relaxation of the smooth muscle of the penile artery. A decrease in vascular tone leads to an increase in penile blood flow and a swelling of the cavernous tissue.
The swollen corpus cavernosum compresses the vein between the corpus cavernosum and the tunica albuga, causing a decrease in blood exudation and an increase in intracavernous pressure, resulting in penile erection. PDE5 is a member of the family of cyclic nucleotide hydrolases capable of hydrolyzing second messenger cGMP. A total of 11 PDEs are known, and PDE5 is the major cGMP hydrolase in the human corpus cavernosum.
When NO is released during sexual stimulation, inhibition of PDE5 can increase the level of cGMP in the penis, thereby enhancing the action of endogenous NO; NO and cGMP are at a low level in the presence of asexual stimulation, so sexual stimulation is PDE5 inhibition. The necessary conditions for the agent to work.
Vardenafil Hydrochloride is rapidly absorbed after oral administration, reaching maximum plasma concentration (C max ) in the fasting state for 15 minutes , peak time (T max ) 90% is 30-120 minutes (average 60 minutes) ). The average absolute bioavailability of oral Vardenafil Hydrochloride is approximately 15% due to the significant first-pass effect. At the recommended dose of 5 – 20 mg, after oral Vardenafil Hydrochloride, the increase in AUC (area under drug concentration-time curve) and Cmax was almost proportional to the dose increase. When Vardenafil Hydrochloride was ingested with a high-fat diet (57% lipid content), the absorption rate of Vardenafil Hydrochloride was reduced, Tmax was prolonged by 60 minutes, and Cmax was reduced by an average of 20%, but AUC was not affected. When Vardenafil Hydrochloride was ingested at the same time as the normal diet (30% fat), its pharmacokinetic parameters (C max , T max , and AUC) were not affected. Therefore, Vardenafil Hydrochloride and food can be taken together or alone.
The average volume of distribution of Vardenafil Hydrochloride to steady state is 208 L. Vardenafil Hydrochloride and its main active metabolite, M1, are highly associated with human plasma proteins (approximately 95%) and this binding is independent of the total concentration of the drug and is reversible. After 90 minutes of taking Vardenafil Hydrochloride in healthy volunteers, the concentration of the drug in the semen does not exceed 0.00012% of the dose.
Metabolism of Vardenafil Hydrochloride powder:
Vardenafil Hydrochloride is mainly metabolized by the liver enzyme system CYP3A4 type, and a small part is metabolized by CYP3A5 and CYP2C9 isoenzymes. The plasma elimination half-life of Vardenafil Hydrochloride is approximately 4-5 hours. The main circulating metabolite (M1) of Vardenafil Hydrochloride in the body is derived from piperazine citrate deethylation, and then M1 continues to metabolize. The plasma elimination half-life of M1 is similar to the prototype drug, which is about 4 hours. In the systemic circulation, part of M1 is a bound glucuronide. The M1 of non-glucuronide in plasma accounts for about 26% of the original drug component. The metabolite M1 has a phosphodiesterase selectivity similar to Vardenafil Hydrochloride. In vitro, M1 inhibits PDE5 by about 28% of Vardenafil Hydrochloride, accounting for 7% of the drug.
Dosage of Vardenafil Hydrochloride powder
Vardenafil Hydrochloride as Levitra has 5 mg, 10 mg, 20 mg formulation. The usual dose is 10 mg and it is the quickest in comparison with sildenafil and tadalafil. It takes effect in about 10 to 30 minutes after taking the effect. Beginning in 10 to 30 minutes after taking the dose, the blood concentration reaches its peak at 45 minutes after taking and the effect lasts about 5 to 8 hours after taking it. It is also the ingredient with the strongest erection strength. Sildenafil is less frequent in side effects compared to sildenafil and it is an improved version of sildenafil.
Recommended dose for Vardenafil Hydrochloride powder:
The recommended starting dose is 10 mg, taken approximately 25-60 minutes before sexual intercourse. In clinical trials, taking 4-5 hours before sexual intercourse, it still shows efficacy. The maximum recommended dose is used once a day. Vardenafil Hydrochloride can be taken with or with food. Sexual stimulation is required as an instinctive response for treatment.
The dose can be increased to 20 mg or reduced to 5 mg depending on the efficacy and tolerability. The maximum recommended dose is 20 mg per day.
Dose of liver dysfunction:
Mild liver dysfunction, no need to adjust the dose; moderate liver dysfunction, the recommended starting dose is 5mg, and then gradually increase to 10mg according to efficacy and drug resistance; severe liver function Incomplete, the dose is not clear.
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